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Abstract

New spectrophotometric methods for estimation of nifedipine.

Author(s): L Bruno, SK John
Dept. of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Medical College, Trivandrum-695 011,

Correspondence Address:
L Bruno Dept. of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Medical College, Trivandrum-695 011

Spectrophotometric methods based on the reaction with vanillin in methanol in phosphoric acid medium and Folin-Ciocalteu reagent in strongly acidic medium are reported for the determination of nifedipine and its dosage forms. The chromagens obtained have absorbances maxima at 400 nm and 740 nm and obey Beer's law in the concentration range of 10-180 mcg/ml and 6-100 mcg/ml respectively.