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Abstract

Niosomal Sumartriptan Succinate For Nasal Administration

Author(s): S Gayathri Devi, Venkatesh, N Udupa

Niosomes of sumatriptan succinate were prepared using lipid hydration method. The prepared niosomes were evaluated for entrapment efficiency, size analysis and in vitro release studies. Further, the niosomes were evaluated for nasal absorption using an ex vivo animal model. The entrapment efficiency was found to be 57.9 ± 0.96 %. The niosomes released 58.71% of sumatriptan succinate over a period of 6 h and 78.1% of the drug was absorbed from the nasal mucosa ex vivo.