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Abstract

Permeation Kinetics Of Diclogenac Sodium From Pseudolatex Transdermal Formulations Through Lipidized And Delipidized Mouse Skin

Author(s): L Panigrahi, Snigdha Pattnaik, S. K Ghosal

A transdermal drug delivery system of diclofenac sodium was developed for prolonged and controlled release of drug. The designed system essentially based on polymeric dispersion system. To achieve the desired release rate, different combinations of hydrophilic and hydrophobic polymers were used for the preparation of pseudolatex systems. The permeation kinetics of diclofenac sodium from transdermal system through hairless delipidized and lipidized mouse skin was done. The permeation profile and the related kinetic parameters of diclofenac sodium alone and in presence of an enhancer isopropyl myristate at different concentrations were studied. The observed permeation flux, permeation coefficient found to increase in presence of enhancer isopropyl myristate. The effect was found to be the maximum with isopropyl myristate at a concentration of 10 percent. The more pronounced enhancing effect of isopropyl myristate regarding permeability flux, permeation coefficient, diffusion coefficient was attributed with solubility parameter being nearer to the skin lipid solubility parameter and probably due to its passage across the skin barrier through the lipid pathway.