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Abstract

Pharmacological studies on solanogantine, a steroidal alkaloid isolated from solanum giganteum JACQ.

Author(s): A Gomes, RM Sharma, AK Chakravarty
Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032,

Correspondence Address:
A Gomes Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032

Solanogantine, a steroidal alkaloid isolated from the leaves of Solanum giganteum Jacq. exhibited dose dependent hypotensive effect in anaesthetised normotensive rats. It also revealed spasmolytic activity against known spasmogens in isolated smooth muscles. The hypotensive action appeared to be due to direct vasodilatation.