All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Physicochemical characterization, in vitro release and permeation studies of respirable rifampicin-cyclodextrin inclusion complexes

Author(s): JS Patil1, Sarasija Suresh2
1 Department of Pharmaceutics, B. L. D. E. A's College of Pharmacy, BLDE University Campus, Bijapur -586 103, India 2 Department of Pharmaceutics, Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560 027, India

Correspondence Address:
Sarasija Suresh Department of Pharmaceutics, Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560 027 India [email protected]


The inclusion complexes of rifampicin with sucralose and β-cyclodextrins were prepared by spray drying method. The complexes were characterized by size analyses, scanning electron microscopy, differential scanning calorimetry and x-ray diffraction methods. The results indicated the amorphous nature of resultant products. The solubility, in vitro release and skin permeation of the drug were enhanced after formation of inclusion complexes. The in vitro release and permeation of the inclusion complexes were greater in simulated lung fluid as compared to pure drug.



Share this