Phytochemical and pharmacological investigation of Hibiscus rosasinensis linn.
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, New Delhi-110 062, India 2 Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, S. S. Nagara, Mysore-570 015, India
Correspondence Address: A A Siddiqui Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, New Delhi-110 062 India E-mail: [email protected]
Three extracts of Hibiscus rosasinensis Linn. have been prepared and evaluated for hypotensive activity. Hydroalcoholic extract was found to exhibit prominent activity when compared to the reference standard minoxidil. In an attempt to isolate the active constituents responsible for this activity from hydroalcoholic extract, five new phytoconstituents were isolated and their structures were elucidated from spectral evidence (IR, NMR and Mass). Hypotensive activity of these isolated compounds was also studied.