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Abstract
Poly (DL Lactic Acid) Microspheres For Controlled Drug Delivery Systems
Author(s): D Vijaya Ramesh, Y Tabata, Y Ikada
A new antiinflammatory drug was entrapped into the ploy (DL lactic acid) PDLLA (MW 3000) microspheres. The microspheres were prepared by an oil-in-oil emulsion polymerization method. The morphology and degradation of the microspheres were analysed by optical and scanning electron microscopy. The in vitro release pattern of the drug from the microspheres was analysed by HPLC. The in vitro degradation and the percent weight loss determination of the PDLLA mictrospheres were also analysed. It was found that the release of the new antiinflammatory drug from the above poly (DL lactic acid) microspheres followed zero order fashion and lasted for about 14 days.
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