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Abstract

Possible beta adrenoceptor blocking agents : synthesis of 6-(3-amino-2-hydroxy propoxy)-3-(methyl) 1, 2-benz-isoxazoles.

Author(s): AR Bhat, KS Raghavan, MN Guruswamy
College of Pharmacy, Manipal and Dept. of Pharmacology, Kasturba Medical College, Manipal-576 119

Correspondence Address:
A R Bhat College of Pharmacy, Manipal and Dept. of Pharmacology, Kasturba Medical College, Manipal-576 119

Certain propanolamine derivatives of 6-hydroxy 1,2-benz-isoxazoles have been synthesised. All the compounds showed varying degree of beta-blocking activity when compared to propranolol, and local anaesthetic action when compared to xylocaine. Results of preliminary pharmacological screenings are given.