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Abstract
Preliminary report of anti-hepatitis C virus activity of chloroquine and hydroxychloroquine in huh-5-2 cell line
Author(s): M Chandramohan1, SC Vivekananthan1, D Sivakumar1, P Selvam2, J Neyts3, G Katrien3, E De Clercq3
1 Bharat Ratna Kamarajar Jaundice, Liver Hospital and Research Centre, Madurai-625 001, India 2 Arulmigu Kalasalingam College of Pharmacy, Krishnankoil-626 190, India 3 Rega Institute of Medical Research, Katholieke University, B-3000, Leuvan, Belgium, India
Correspondence Address:
M Chandramohan Bharat Ratna Kamarajar Jaundice, Liver Hospital and Research Centre, Madurai-625 001 India E-mail: kamaraj_liver_hospital@yahoo.com
1 Bharat Ratna Kamarajar Jaundice, Liver Hospital and Research Centre, Madurai-625 001, India 2 Arulmigu Kalasalingam College of Pharmacy, Krishnankoil-626 190, India 3 Rega Institute of Medical Research, Katholieke University, B-3000, Leuvan, Belgium, India
Correspondence Address:
M Chandramohan Bharat Ratna Kamarajar Jaundice, Liver Hospital and Research Centre, Madurai-625 001 India E-mail: kamaraj_liver_hospital@yahoo.com
Chloroquine and hydroxychloroquine screened for antiviral activity against Hepatitis C virus in Huh-5-2 cells. Chloroquine and hydroxychloroquine reduces the HCV RNA and promote the cell growth with respect to untreated control at concentration of 10.75 µM and 6.6 µM respectively.
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