Preliminary studies on the development of a new non-bitter chloroquine formulation using tannic acid.
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur-440010
S V Fulzele Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur-440010
Chloroquine phosphate is a biter antimalarial drug belonging to the 4-amino quinoline class of compounds. It was treated with tannic acid and precipitated to form a poorly soluble complex. The complex was analysed and evaluated for taste and in vitro release. It was then formulted in a syrup base. When orally administered to healthy human subjects, chloroquine level comparable to marketed preparation was obtained. On the basis of the preliminary results obtained in the present study the method may be further evaluated as a technique for teste masking of bitter amine drugs.