Preparation and Characterization of Ganciclovir-loaded Glutathione Modified Gold Nanoparticles
Department of Pharmaceutical Sciences, S Bhagwan Singh PG Institute of Bio-medical Sciences and research, Balawala, Dehradun-248 161, India
Department of Pharmaceutical Sciences, S Bhagwan Singh PG Institute of Bio-medical Sciences and research, Balawala, Dehradun-248 161, India Email: [email protected]
In this research, ganciclovir-loaded gold nanoparticles were developed via glutathione surface modification. First citrate reduced gold nanoparticles were prepared from chloroauric acid. Further the surface of gold nanoparticles was also modified with glutathione. Then ganciclovir was loaded onto glutathione modified gold nanoparticles through the reaction between carboxyl group of glutathione and amino group of ganciclovir. Gold nanoparticles were characterized by photon correlation spectroscopy, transmission electron microscopy and infrared spectroscopy. The drug loading of 87.27±2.52% was observed for ganciclovir loaded gold nanoparticles. The particle size distribution of gold nanoparticles was ranged from 26.3 to 31 nm. Thus ganciclovir loaded gold nanoparticles were successfully prepared which may further improve the oral bioavailability of ganciclovir.