All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Preparation And Characterization Of Mutual Prodrugs Of Ibuprofen

Author(s): A. V Bhosale, G. P Agrawal, P Mishra

Ibuprofen was esterified with paracetamol and salicylamide to give two mutual prodrugs. The purity of the compounds was confirmed by TLC. Prodrugs were characterized on the basis of elemental analysis, IR spectroscopy, [1H] NMR spectroscopy and mass spectroscopy. The physicochemical properties such as solubility in water and organic solvents like methanol, ethanol, acetone, chloroform and ether, and partition coefficient in octanol-water, octanol-hydrochloric acid buffer (pH 1.2), and in octanol-phosphate buffer (pH 7.4) were determined. The results indicate that the prodrugs are more lipophilic than parent drug i.e. ibuprofen and their dissolution rate was pH-dependent.

PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report