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Abstract

Preparation And Evaluation Of Alginate Microspheres Containing Norfloxacin And Ciprofloxacin

Author(s): K. S Aithal, N Udupa

Microspheres containing norfloxacin and ciprofloxacin using Sodium and calcium alginates were prepared and the possible drug-excipient chemical interaction was evaluated by various spectral methods. There was no chemical interaction between these drugs and the alginates. The dissolution and diffusion of these drugs were delayed and the stability at various accelerated stability conditions was improved on entrappment of these drugs in alginates.