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Abstract

Preparation And Evaluation Of Muco-Adhesive Buccal Tablets Of Hydralazine Hydrochloride

Author(s): Dinsheet S. P Agarwal, Alka Ahuja

Multilayered muco-adhesive buccal tablets of hydralazine hydrochloride were developed using polymers, which as Carbopol- 934 and carboxymethylcellulose. Release enhancers such as citric acid, D-mannitol and PEG-4000 and techniques like lyophilization were utilized for optimization of the tablet core. A Millipore membrane filter (0.22mm) was used satisfactorily to replace animal membrane for drug permeation studies across the membrane.