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Abstract

Preparation and evaluation of sustained release nimesulide microspheres prepared from sodium alginate.

Author(s): VB Patil, VB Pokharkar Department of Pharmaceutics, Bharati Vidyapeeth's Poona College of Pharmacy and Research Centre, Erandwane, Pune-411038
Department of Pharmaceutics, Bharati Vidyapeeth's Poona College of Pharmacy and Research Centre, Erandwane, Pune-411038

Correspondence Address:
V B Patil Department of Pharmaceutics, Bharati Vidyapeeth's Poona College of Pharmacy and Research Centre, Erandwane, Pune-411038

Nimesulide-loaded calcium alginate beads were prepared. In this investigation, a 2(3) full factorial design was used to study the joint influence of three variables, the polyemer concentration (X(1), the drug concerntration (X(2) and the cross-linker (calcium chloride) concentration (X(3), on various dependent variables like per cent entrapment, sphericity, particle size and amount of drug released during the initial (t=60 min) and final stages (t=360 min) of release. A statistical model with a significant interaction term is obtained to predict the results. The drug release mechanisms from microspheres were studied using the Peppas equation.