All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Preparation of a Menthol/beta-Cyclodextrin Inclusion Complex Using Supercritical CO2

Author(s): H. P. Lei, H. Zhang, F. H. Ge1*, Zh. W. Ye and Ch. H. Li2
School of Pharmaceutical Sciences, Xiangnan University, Chenzhou 423000, 1School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, 2School of Chemistry Biology and Environmental Engineering, Xiangnan University, Chenzhou 423000, China

Correspondence Address:
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China, E-mail: gefahuan@163.com


A menthol/β-cyclodextrin inclusion complex was produced using supercritical CO2 while varying the temperature, pressure, co-solvent, inclusion time and depressurization time. The complex resulted was characterized with X-ray diffraction, scanning electron microscopy and differential scanning calorimetry. The characterization data confirmed the production of the inclusion complex at a maximum yield of 93.75 %. The dissolution rate of the complex was signiï¬?cantly higher than those of either untreated menthol or a physical mixture of menthol and β-cyclodextrin. This work thus demonstrated that supercritical CO2 could be successfully used to achieve inclusion complexes of menthol with β-CD.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report