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Abstract
Preparation of mucoadhesive microspheres for nasal delivery by spray drying
Author(s): Mahalaxmi Rathananand1, DS Kumar1, A Shirwaikar1, Ravi Kumar1, D Sampath Kumar2, RS Prasad1
1 Department of Pharmaceutics, Manipal college of Pharmaceutical Sciences, Manipal - 576 104, India 2 Orchid Healthcare Ltd., Plot no.476/14, Old Mahabalipuram Road, Sholinganallur, Chennai - 600 119, India
Correspondence Address:
Mahalaxmi Rathananand Department of Pharmaceutics, Manipal college of Pharmaceutical Sciences, Manipal - 576 104 India E-mail: mlrcops2002@yahoo.co.in
1 Department of Pharmaceutics, Manipal college of Pharmaceutical Sciences, Manipal - 576 104, India 2 Orchid Healthcare Ltd., Plot no.476/14, Old Mahabalipuram Road, Sholinganallur, Chennai - 600 119, India
Correspondence Address:
Mahalaxmi Rathananand Department of Pharmaceutics, Manipal college of Pharmaceutical Sciences, Manipal - 576 104 India E-mail: mlrcops2002@yahoo.co.in
In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug. The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in terms of particle size and release properties. The conditions of the spray dryer were optimized for production yield and particle size.
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