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Abstract

Pyridopyrimidines : part iii-synthesis and analgesic activity of 4-aminopyrido [2,3-d] pyrimidines

Author(s): CG Dave, PR Shah, GK Shah, PS Pandya, KC Dave, VJ Patel
Dept. of Chemistry, St. Xavier's College, Ahmedabad-380 009

Correspondence Address:
C G Dave Dept. of Chemistry, St. Xavier's College, Ahmedabad-380 009

2-Amino-3-cyano-4-substituted-5-phenylpyridines (I) when reacted with formamide, urea and thiourea, 4-amino-5-substituted-7-phenylpyrido [2,3-d] pyrimidines (II), 4-amino-5-substituted-7-phenylpyrido [2,3-d] pyrimidin-2 (1H)-ones (III) and 4-amino-5-substituted-7-phenylpyrido [2,3-d]-pyrimidin-2 (1H)-thiones (IV) were obtained respectively. Some of the synthesized compounds II, III and IV were tested for analgesic activity.