Regulation Of Skin Lipid Biosynthesis : Role In Transcutaneous Permeation Enhancement
Stratum corneum lipids form the major portion of skin constituents. Their synthesis and metabolism regulate the epidermal structural organization and barrier function. An alteration of their content is a good indicator of various skin diseases. The barrier function can be modified by employing epidermal lipid metabolic inhibitors. This approach can be advantageously utilized to increase the transcutaneous delivery of drugs. Hence, it is imperative to study the factors that influence the synthesis and metabolism of epidermal ceramide, cholesterol and fatty acids and their role in barrier homeostasis.