All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Regulation Of Skin Lipid Biosynthesis : Role In Transcutaneous Permeation Enhancement

Author(s): O Anand, S Gupta, A. K Tiwary

Stratum corneum lipids form the major portion of skin constituents. Their synthesis and metabolism regulate the epidermal structural organization and barrier function. An alteration of their content is a good indicator of various skin diseases. The barrier function can be modified by employing epidermal lipid metabolic inhibitors. This approach can be advantageously utilized to increase the transcutaneous delivery of drugs. Hence, it is imperative to study the factors that influence the synthesis and metabolism of epidermal ceramide, cholesterol and fatty acids and their role in barrier homeostasis.