Release Enhancement And Reduction In Ulcerogenicity Of Naproxen By Polyvinylpyrrolidone
Solid dispersion of naproxen (NPX) was prepared with polyvinylpyrrolidone (PVP) by solvent method. The spectroscopic studies of the dispersion indicated the interaction of NPX with PVP mainly through hydrogen bonding between the carboxylic acid group and the nitrogen of the pyrrolidone ring of PVP. Aqueous solubility of NPX was found to increase with a corresponding increase in PVP levels. A marked increase in drug release was also observed. It was found that NPX:PVP complex system in a dose corresponding to NPX, 29 mg/Kg p.o., exhibited ulcer protecting effect in rats.