All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Release Rate Of Nimesulide From Different Gellants

Author(s): G. D Gupta, R. S Gaud

Nimesulide (NM) gels were formulated employing different gallent such as Carbopol-940, PEG-6000, PEG-4000, HPMC, Sod-CMC and Sodium alginate in different proportion. These formulations were evaluated for drug content, viscosity, pH, extrudability, homogeneity, irritation, spreadability and release pattern through a cellophane membrane using Fites cyclindrical tube. In vitro release studies of NM from different gels were compared with a marketed NM Gel preparation. Carbopol-940 with and without menthol and PEG-6000 with sodium carboxy methyl cellulose bases of NM Gels showed good release pattern compared to other gals.