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Abstract

Release Studies Of Nimesulide From Ethyl Cellulose And Ethyl Cellulose And Hydroxy Propyl Methyl Cellulose Matrices

Author(s): K.E.V Nagoji, S Srinivasa Rao, M.E Bhanoji Rao

Spherical matrices of nimesulide were prepared by using ethyl cellulose alone and a combination of ethyl cellulose and hydroxy propyl methyl cellulose by spherical agglomeration technique and the drug release from these matrices 20/40 and 40/60 size was studied for 8 h. It was found that the drug release from ethyl cellulose matrices was slow compared to that from the combined polymer matrices. The improved drug release from the combined polymer matrices appears to be due to improved solubility of the drug in the presence of hydroxy propyl methyl cellulose.