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Abstract

Rosin Derivative As Hydrophobic Matrix Material For Controlled Release Of Diclofenac Sodium

Author(s): P. M Satturwar, S. V Fulzele, P. M Mandaogade, G. N Darwhekar, A. K Dorle

New rosin derivative (R-1) as a hydrophobic matrix material for the controlled release of drugs is reported, using diclofenac sodium as model drug. Matrix tablets were prepared by wet granulation method using R-1 as matrix forming material in different proportions and combinations. The matrix tablets were evaluated for thickness, hardness, friability, weight variation, drug content uniformity and in vitro dissolution. The results suggest that the new rosin derivative (R-1) is useful in developing sustained release matrix tablets, with drug release being prolonged for upto 10 h. R-1 thus promises considerable utility in the development of oral sustained release drug delivery systems.