All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

RP-HPLC estimation of tizanidine HCl and valdecoxib in combined dosage forms

Author(s): AS Bhavsar, GS Talele, RA Fursule, SJ Surana
Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Karvand Naka, Shirpur-425 405, India

Correspondence Address:
G S Talele Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Karvand Naka, Shirpur-425 405 India E-mail: gstalele@rediffmail.com


A reverse phase high performance liquid chromatography method was developed for simultaneous estimation of tizanidine HCl and valdecoxib in tablet formulation. The separation was achieved by Luna C 18 column and acetonitrile: phosphate buffer pH 3.5 (50:50 v/v) as eluent, at a flow rate of 0.5 ml/min. Detection was carried out at 227 nm. Etoricoxib was used as an internal standard. The retention time of tizanidine and valdecoxib was found to be 4.43 and 16.60 min, respectively. The method was validated for linearity, accuracy and precision. Linearity for tizanidine and valdecoxib were in the range 0.4-2.0 µg/ml and 4-20 µg/ml, respectively. The developed method was found to be accurate, precise and selective for simultaneous estimation of tizanidine and valdecoxib in tablets.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report