RP-HPLC method for the simultaneous determination of Atorvastatin and Amlodipine in tablet dosage form
Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram-534 202, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India.
GG Sankar Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram-534 202, India E-mail: [email protected]
A simple, precise, accurate, and rapid HPLC method has been developed, and validated for the determination of atorvastatin and amlodipine simultaneously, in combined tablet dosage form. The mobile phase used was a mixture of acetonitrile and 0.03M phosphate buffer pH 2.9 (55:45% v/v). The detection of atorvastatin and amlodipine was carried out on dual γγγγγ absorbance detector at 240 nm and 362 nm, respectively. Results of the analysis were validated statistically, and by recovery studies. The proposed method can be successfully used to determine the drug contents of marketed formulation.