Simultaneous determination of clopidogrel and aspirin in pharmaceutical dosage forms
Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, India
P Mishra Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, India E-mail: [email protected]
Two simple spectrophotometric methods for the determination of aspirin and clopidogrel in pharmaceutical formulations have been developed. First method is based on the additivity of absorbances. Second method is based on the determination of graphical absorbance ratio at two selected wavelengths, one being the isoabsorptive point for the two drugs (225 nm) and the other being the absorption maximum of hydrolysed aspirin (235.7 nm). Beer Lambert's law is obeyed for both the drugs in the concentration range 4-18 mg/ml. Both the methods were found to be simple, rapid, accurate and can be adopted in routine analysis of drugs in formulations. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.