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Abstract

Simultaneous determination of mefenamic acid and paracetamol from combined dosage forms by spectrophotometry.

Author(s): AS Dhake, DB Sonaje, VS Kasture, PT Nikam, RS Talekar
N.D.M.V.P. Samaj's College of Pharmacy, Shivajinagar, Gangapur Road, Nashik-422002

Correspondence Address:
A S Dhake N.D.M.V.P. Samaj's College of Pharmacy, Shivajinagar, Gangapur Road, Nashik-422002

A new simple and sensitive spectrophotometric method in the UV region has been developed for the simultaneous determination of mefenamic acid and paracetamol in bulk and in dosage forms. Mefenamic acid shows three absorbance maxima at 257 nm in 0.1N sodium hydroxide. Absorbance corrected for interference was used for estimation. Both these drugs obey Beer's law in the concentration ranges used in this method. The method has been validated statistically and by recovery studies.