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Abstract

Simultaneous Estimation Of Losartan Potassium And Hydrochlorthiazide In Combination

Author(s): M Gandhimathi, K Vikram, A Baskaran, T. K Ravi

A simple and accurate method for the Simultaneous estimation of losartan potassium (LP) and hydrochlorthiazide (HZ) has been developed-The method employs simultaneous equations to estimate these drugs. In methanol, losartan potassium and hydrochlorthiazide showed maximum absorbance at 236 and 270 nm respectively. Losartan potassium and hydrochlorthiazide obeyed Beer Lambert's law in the concentration range from 2-20μg/ml and 1-50μg/ml, respectively. The results of analysis have been validated statistically and by recovery studies.