Simultaneous estimation of ranitidine and domperidone in combined dosage form
Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University Campus, Amrawati Road, Nagpur-440 033, India
M S Charde Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University Campus, Amrawati Road, Nagpur-440 033 India E-mail: [email protected]
The development of Vireodt's method for simultaneous estimation of ranitidine and domperidone involves absorbance measurement at 326 nm and 287 nm corresponding to the respective absorption maxima. Both the drugs obey Beer Lambert's law in the range of 3.0-50 µg/ml for ranitidine and 0.2-3.5 µg/ml for domperidone. The tablet formulation (Random, Mankind) was evaluated for the percent content of both the drugs at the selected wavelengths. The method developed was validated to determine its accuracy, precision, specificity and ruggedness. The recovery study was carried out by standard addition method. The average percent recovery was found to be 99.65±0.47 for ranitidine and 100.06±0.18 for domperidone.