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Abstract

Simultaneous Estimation Of Valdecoxib And Tizanidine By Vierodt's And Q-Analysis UV Spectrophotometric Method

Author(s): Vaishali Nagulwar, M. R Tajne, Kanchan Upadhye, Suparna Bakhle, Shilpa Deshpande, Rita Wadetwar

The simple, accurate and precise Vierodt's and Q-analysis UV Spectrophotometric method has been developed for the simultaneous determination of valdecoxib and tizanidine in combined tablet dosage form. Shimadzu UV-1601 instrument was used and the λmax of valdecoxib and tizanidine was found to be 237 nm and 319 nm, respectively. In Q-analysis, the isoabsorptive point for both the drugs was found at 289.5 nm. The linearity range lies between 5-30 μg/ml for valdecoxib and 0.5-3 μg/ml for tizanidine at their respective wavelengths.