Simultaneous Spectrophotometric Analysis Of Phenylpropanolamine Hydrochloride Chloropheniramine Maleate And Dextromethorphan Hydrobromide In Syrups
Present communication deals with two simple and economical methods requiring no prior separation for simultaneous analysis of phenylpropanolamine hydrochloride, chloropheniramine maleate and dextromethorphan hydrobromide in combination in pharmaceutical formulations. The methods employ multicomponent analysis procedure and simultaneous equations after spectral manipulation for quantification. In 0.1 N hydrochloric acid, phenylpropanolamine hydrochloride has an absorbance maxima at 257 nm, chloropheniramine maleate at 265 nm and dextromethorphan hydrobromide at 278 nm. All three drugs obey Beer's law in the concentration range employed for these methods. The linearity was validated by Least Squares method. The results of analysis have been validated statistically and by recovery studies. Both methods are simple, accurate, reproducible and rapid.