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Abstract

Simultaneous spectrophotometric determination of benzoic acid and salicylic acid contents in ointment by least squares method in matrix form.

Author(s): KK Mahalanobis, D Basu, B roy
Dept. of Chemistry, Jadavpur University, Calcutta-700 032,

Correspondence Address:
K K Mahalanobis Dept. of Chemistry, Jadavpur University, Calcutta-700 032

Least squares method in matrix form is described for simultaneous determination of benzoic acid and salicylic acid in oinment without prior separation from each other. The concentration of each component has been determined spectrophotometrically measured at 5nm intervals from 230 to 300 nm. The mean percentage recovery and standard deviation of content in ointment is 98.86 +/- 2.93 for benzoic acid and is 100.36 +/- 3.03 for salicylic acid.