Simultaneous Spectrophotometric Determination Of Mefenamic Acid And Paracetamol In Combined Pharmaceutical Dosage Forms
A simultaneous spectrophotometric procedure for mefenamic acid and paracetamol in two component tablet formulations has been developed. The method is based on two-wavelength method of calculations. The difference in absorbances at 217 nm and 285 nm was used for determination of mefenamic acid and the difference in absorbances at 257 nm and 308.8 nm was used for determination of paracetamol. Beer's law is obeyed by both the drugs within the concentration ranges employed for analysis. The method has been statistically validated and was found to be satisfactory.