Simultaneous Spectrophotometric Determination Of Tizanidine And Diclofenac In Tablets
Two simple, precise and accurate methods for simultaneous estimation of tizanidine hydrochloride and diclofenac sodium in combined dosage form have been described. Method 1 involves formation of Q-absorbance equation at 296 nm (isoabsorptive point) and at 281.3 nm while method 2 involves formation of simultaneous equation at 281.3 and 317.1 nm using methanol as solvent. Both the methods were validated and the results were compared statistically. They were found to be precise, accurate, and specific. The proposed methods were successfully applied to estimation of tizanidine and diclofenac in combined tablet formulation.