Simultaneous spectrophotometric determination of Valdecoxib and Tizanidine in tablets
Department of Chemistry, Pharmaceutical Chemistry Unit, Vellore Institute of Technology, Deemed University, Vellore -632 014, India
Lakshmi Sivasubramanian Department of Chemistry, Pharmaceutical Chemistry Unit, Vellore Institute of Technology, Deemed University, Vellore -632 014 India E-mail: [email protected]
Two simple, precise and accurate methods for simultaneous estimation of valdecoxib and tizanidine in combined dosage form, have been described. Method 1 involves formation of Q-absorbance equation at 239.6 (isoabsorptive point) and at 241 nm, while method 2 involves formation of simultaneous equation at 241 and 229 nm, using methanol as solvent. Both the methods were validated, and the results were compared statistically. They were found to be precise, accurate, and specific. The proposed methods were successfully applied to estimation of valdecoxib and tizanidine in combined tablet formulation.