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Abstract

Simultaneous Spectrophotometric Estimation Of Chlorzoxazone And Nimesulide From Combined Dosage Form.

Author(s): U. N Kale, K. R Naidu, M. S Shingare

A simple, accurate and economical procedure for simultaneous estimation of chlorzoxazone and nimesulide in two component tablet formulations have been developed. The method is based on the UV absorbance maxima in 0.1N sodium hydroxide. Chlorzoxazone has two absorbance maxima at 243 and 288 nm while nimesulide has an absorbance maximum at 393 nm. Both drugs obey Beer's law in the concentration range of 2-40 µg/ml. The results of analysis have been validated statistically and by recovery studies.