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Abstract

Simultaneous Spectrophotometric Estimation Of Gatifloxacin And Ornidazole In Mixture

Author(s): P. U Patel, B. N Suhagia, C. N Patel, M. M Patel, Gaythri C Patel, Geeta M Patel

Two simple, rapid, accurate and economical methods have been developed for the estimation of gatifloxacin and ornidazole in the mixture. Gatifloxacin has absorbance maxima at 286.2 nm and ornidazole has absorbance maxima at 319 nm in distilled water. The linearity was observed in the concentration range of 2-14 μg/ml for gatifloxacin and 2-20 μg/ml for ornidazole. First method is based on the simultaneous equations and second method is based on Q-absorbance ratio. Absorbances at isoabsorptive point 299.2nm and at the λ-max of ornidazole. These methods were validated statistically. The recovery studies confirmed the accuracy of the proposed methods.