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Abstract

Simultaneous Spectrophotometric Estimation Of Ibuprofen And Methocarbamol In Tablet Dosage Form

Author(s): T. R. S Satheeshmanikandan, Deepa C Wali, J Bariwal, S. S Kadam, S. R Dhaneshwar

Two simple economical procedures for simultaneous estimation of ibuprofen and methocarbamol in two-component tablet formulation have been developed. The method employs Q-analysis and two-wavelength method. Ibuprofen has absorbance at 222 nm and-methocarbamol has absorbance maxima at 224 nm and 272 nm. The isoabsorptive point of ibuprofen and methocarbamol was found to be 231.4 nm. Both drugs obeyed the Beer's law in the concentration ranges employed for these methods. The results have been validated statistically and by recovery studies.