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Abstract

Simultaneous Spectrophotometric Estimation Of Nalidixic Acid And Metronidazole In Combined Dosage Forms

Author(s): Vaishali Nagulwar, P. A Upadhye, N. K Mehta, Kanchan Upadhye, Suparna Bakhle, Shilpa Deshpande, Gouri Dixit

Nalidixic acid and metronidazole in combination are routinely used as antidiarrhoeal. The present investigation attempts to develop estimation method for these two drugs in combined dosage forms. It was found that both the drugs follow the Beer's Law from 2.0-10.0 μg/ml and 2.0-12.0 μg/ml at 257 and 277 nm, respectively. The absorptivity (1%, 1 cm), values at the specified wavelengths for nalidixic acid was found to be 1232.84 and 211.05, respectively and for metronidazole 263.65 and 376.18, respectively. Thus, the present method is simple, rapid and accurate and is based on the principle of simultaneous UV spectrophotometric determination of binary mixture.