All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Solid dispersions of clofazimine with improved dissolution.

Author(s): GS Rani, D Venkatramana, JS Kumar, DR Krishna, Shobha Rani G, Surya Kumar J
University College of Pharmaceutical Sciences, Kakatiya University. Warangal-506 009 (AP),

Correspondence Address:
G S Rani University College of Pharmaceutical Sciences, Kakatiya University. Warangal-506 009 (AP)

Clofazimine is one of the important drugs used in the multi drug therapy of leprosy. Being highly lipophilic, it is practically insoluble in water and and has a variable oral bioavailability in man.Physical mixtures and solid dispersions of clofazimine with mannitol and polyethylesglycol 6000 in different drug- carrier ratios were prepared in an attempt to improve its dissolution. Differential thermal analysis (DTA), X-ray diffraction (XRD) analusis and dissolution studies were performed to evaluate the formulations. The dissolution rate of clofazimine was markedly increased in solid dispersions of PEG 6000 as well as mannitol. The former material was more promising as a carrier. DTA and XRD studies revealed that clofazimine does not enter crystal lattice of the two carriers studied.

PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report