Solubility Enhancement of Lornoxicam by Crystal Engineering
Shri Bhagwan College of Pharmacy, CIDCO N-6, Aurangabad-431 003, School of Pharmacy, S. R. T. M. University, Vishnupuri, Nanded-431 606, India
School of Pharmacy, S. R. T. M. University, Vishnupuri, Nanded-431 606, India E-mail: [email protected]
An attempt was made to improve the solubility and physicochemical properties of the poorly soluble lornoxicam by crystal engineering with different coformers. Nineteen different coformers were screened during this study. Cocrystals were prepared by neat grinding method. The prepared cocrystals were evaluated for solubility, powder characteristics, assay and in vitro dissolution study. The solid state property was characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, powder X-ray diffraction analysis and Raman spectroscopy. Maximum solubility and dissolution rate were observed with cocrystal prepared using saccharin sodium. Cocrystallization leads to increased solubility and improved in vitro dissolution of lornoxicam.