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Abstract

Solubility studies of tolbutamide in separate or mixed aqueous systems

Author(s): VF Naggar, AG Eshra
Dept. of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

Correspondence Address:
V F Naggar Dept. of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

Piperazine citrate, urea and glycine increased the solubility of tolbutamide, while sodium chloride decreased it. The solubility data in sodium chloride-urea or glycine solutions suggest interaction. Ureaglycine system gave less than additive effects.