All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Solubilization Of Nimesulide; Use Of Co-Solvents

Author(s): Neelam Seedher, Jaspreet Kaur

Solubility of nimesulide in various solvents and solvent-co-solvent mixtures was determined in relatlon to the development of parenteral formulations. Solubility was low in aqueous solvents. Solubility Increased on solubilization of drug in semi-polar solvents and non-ionic surfactants. Solubility increased drastically (>70 mg/rnl) when polyethylene glycol 300 and polyethylene glycol 400 were used as solvents. The minimum concentration of polyethylene glycol required for solubility to be greater than 50 mg/ml was found to be 80%. It was recommended that solvent containing 90% polyethylene glycol and 10% co-solvent (alcohol, propylene glycol,Tween 80 and Brij 30) with solubility greater than 65 mg/ml can be used in parenteral formulations of nimesuilde. Alternatively 8% co-solvent can be mixed with 2% benzyl alcohol which acts as an anaesthetic agent.