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Abstract

Solvent deposition of chlordiazepoxide on starch-lactose granules

Author(s): AP Kakkar, R Gulati, AK Bansal
Dept. of Pharmaceutics, College of Pharmacy, (University of Delhi), Pushp Vihar, Sector 3, New Delhi 110 017,

Correspondence Address:
A P Kakkar Dept. of Pharmaceutics, College of Pharmacy, (University of Delhi), Pushp Vihar, Sector 3, New Delhi 110 017

Solvent deposition of Chlordiazepoxide on starch-lactose in different proportion in Granules was done using evaporation technique. The tablets prepared using solvent deposition technique and conventional wet granulation technique have been compared for content uniformity and dissolution rate. The product have been characterised using X- ray diffraction studies, scanning electron mocroscopy and differential scanning calorimetry. The results revealed that solid state crystalline transition and not the molecular micronisation, were responsible for increased dissolution rates.