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Abstract

Spectrofluorimetric determination of trimeprazine tartrate and methdilazine hydrochloride in formulations.

Author(s): C SP Sastry, A SRP Tipirneni, MV Suryanarayana, TT Rao, T Satyanarayana
Foods and Drugs Laboratory, School of Chemistry Andhra University, Visakhapatnam-530 003,

Correspondence Address:
C SP Sastry Foods and Drugs Laboratory, School of Chemistry Andhra University, Visakhapatnam-530 003

A simple and rapid spectrofluorimetric method for the determination of trimeprazine tartrate (TMT) and methdilazine hydrochloride (MDH) were developed based on the formation of base catalysed condensation of mixed anhydride with malonic acid/acetic anhydride and tertiary amine groups of the above mentioned drugs in bulk and pharmaceutical preparations.