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Abstract

Spectrophotometric Determination Of Betaxolol Hydrochloride And Metoprolol Tartrate

Author(s): K.V Kanna Rao, B.V.V Ravi Kumar, M.E Bhanoji Rao, S.S Rao

A simple, sensitive and accurate spectrophotometric method has been developed for the determination of betaxolol hydrochloride and metoprolol tartrate in bulk and from pharmaceutical dosage forms. This is an indirect method for the estimation of betaxolol hydrochloride and metoprolol tartrate, which involves oxidation of drug by N-bromosuccinimide and estimation of unreacted N-bromosuccinimide with metol-sulphanilamide reagent. The charge transfer complex so formed is estimated at 520 nm. Both the drugs obey Beer's law in the concentration range of 4-40 mg/ml.