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Abstract

Spectrophotometric determination of febendazole.

Author(s): SP Chudasama
Dept. of Chemistry, College of Science, University of Bahrain, P.O. Box 320 38, Isa Town, Bahrain

Correspondence Address:
S P Chudasama Dept. of Chemistry, College of Science, University of Bahrain, P.O. Box 320 38, Isa Town, Bahrain

A simple spectrophotometric method for the determination of febendazole by hydroxamic acid formation in dosage forms is described. Febendazole reacts with hydroxylamine hydrochloride in alkaline medium to give hydroxamic acid, which forms a reddish violet coloured complex with Iron (III) in acidic medium having maximum absorbance at 500 nm, molar absorptivity of 5.0 x 10 (3) 1.mol(-1) cm(-1).