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Abstract

Spectrophotometric Determination Of Propranolol Hydrochloride In Phramaceutical Preparations

Author(s): Aparna G Sajjan, J Seetharamappa, Saraswati P Masti

Two simple, sensitive and accurate spectrophotometic methods are described for the determination of propranolol hydrochloride either in pure form or in pharmaceutical preparations. Each method involves nitration of the drug with uranyl nitrate or thorium nitrate in sulphuric acid medium. The yellow coloured nitro derivative has an absorption maximum at 377 nm. The nitro derivative obeys Beer's Law In the concentration range of 2-32 µg/ml and 1-30 µg/ml for uranyl nitrate and thorium nitrate respectively. The optium reaction conditions and other analytical parameters are evaluated. The influence of substrates commonly employed as excipients with propranolol drug has been studied. Results of analysis of pure drug and its dosage forms by the proposed methods are in good agreement with those of the official method.