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Abstract

Spectrophotometric Determination Of Rifampicin And Isoniazid In Pharmaceutical Preparations

Author(s): R. B Kakde, A. V Kasture, S. G Wadodkar

Three simple Spectrophotometric methods for the determination of rifampicin (RIF) and isoniazid (INH) in pharmaceutical preparations have been developed. First method is based on the determination of graphical absorbance ratio at two selected wavelengths. In the second method, derivative spectroscopy is used to eliminate spectral interference and the third method is based on additivity of absorbances. All the three methods were found to be simple, rapid, accurate and can be adopted in routine analysis of drug in formulations.