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Abstract

Spectrophotometric Estimation Of Repaglinide In Bulk Drug And Tablet Formulations

Author(s): B. G Chaudhari, S. J Rajput, P. B Shah

Ion-pair extractive spectrophotometric method was developed for the estimation of repaglinide. This method is based on the formation of an yellow colored ion-pair complex with bromothymol blue in presence of acid phthalate buffer (pH 2.4). This complex was then extracted with chloroform. The color of resulting solution was determined at λmax 438 nm. The calibration curve was found to be linear in the range of 5 to 25 μg/ml. The recovery study values ranges from 98 to 100% and % RSD was found to be 1.183.The LOD and LOQ were found t o be 0.97 μg/ml and 3.25 μg/ml, respectively. The method was found to be precise, accurate and sensitive. The method can be successfully applied for its tablet formulation.